Sascha Ott

This study identifies EBV-host gene interactions and shows that the ubiquitin-proteasome system (UPS) is linked to immune evasion, stemness, and poor prognosis in EBV-associated nasopharyngeal carcinoma.

The frequency of menstrual cycles with a suboptimal decidual reaction determines the recurrence risk of miscarriage.

The paper identifies highly conserved cis-regulatory modules in zebrafish and human endoderm that control vertebrate organogenesis and are enriched for neuro-pancreatic transcription factor binding sites.

The paper updates the EnteroBase platform with new data and tools for genomic epidemiology of bacterial pathogens, including antimicrobial resistance detection and visualization features.

The paper identifies distinct macrophage phenotypes in endometriosis using single-cell analysis, linking them to disease-promoting and resolving functions.

TimeTeller estimates circadian clock function from single transcriptomes by modeling the multi-dimensional state of the clock, demonstrating its application across species and data types.

The paper uses single cell ATAC-seq to study chromatin remodeling in human endometrium across the menstrual cycle, identifying dynamic chromatin regions and their role in implantation.

The paper shows that neuroinflammation in OPCs causes major transcriptomic changes by exploiting a primed epigenetic landscape rather than altering chromatin accessibility, leading to white matter injury.

This study identifies immediate DNA methylation changes in the mouse prenatal cortex after alcohol exposure, linking them to gene expression and neurodevelopmental processes.

The paper links a pro-senescent decidual response during the peri-implantation window to recurrent pregnancy loss, showing that immune surveillance failure leads to progesterone-resistant cells and increased miscarriage risk.

The paper identifies cell type-specific immune responses in Arabidopsis roots using transcriptome analysis of elicitors, showing that cell identity networks integrate with immunity networks.