Genetic dissection of DNA damage response pathways reveals divergent modulation of PD-1 blockade response in colorectal cancer
Ferran Fece de la Cruz, Edmond Wong, Haley Barnes, Katerina A. Fella, Jacquelyn M. Curtis, Sarah Phat, David T. Myers, Parasvi S. Patel, Jonathan Braverman, Ömer H. Yilmaz, Ryan Bruce Corcoran
This study identifies DDR gene alterations that modulate PD-1 blockade response in MSS colorectal cancer, showing that some defects enhance immunotherapy while others reduce benefit.
bioRxiv · Oct 6, 2026 · PreprintCancer Biology