Author

Parasvi S. Patel

Harvard UniversityORCID 0000-0002-0326-7902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron N. HataiD· 1 shared Ajinkya S. KawaleiD· 1 shared Caroline R. CrosbyiD· 1 shared Christopher S. NabeliD· 1 shared David T. MyersiD· 1 shared Edmond WongiD· 1 shared Eugene OhiD· 1 shared Ferran Fece de la CruziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Aaron N. HataORCID

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2 papers

Recent·Most cited

Genetic dissection of DNA damage response pathways reveals divergent modulation of PD-1 blockade response in colorectal cancer

Ferran Fece de la Cruz, Edmond Wong, Haley Barnes, Katerina A. Fella, Jacquelyn M. Curtis, Sarah Phat, David T. Myers, Parasvi S. Patel, Jonathan Braverman, Ömer H. Yilmaz, Ryan Bruce Corcoran

This study identifies DDR gene alterations that modulate PD-1 blockade response in MSS colorectal cancer, showing that some defects enhance immunotherapy while others reduce benefit.

bioRxiv · Oct 6, 2026 · PreprintCancer Biology

Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells

Sneha Saxena, Christopher S. Nabel, Turner W. Seay, Parasvi S. Patel, Ajinkya S. Kawale, Caroline R. Crosby, Helene Tigro, Eugene Oh, Matthew G. Vander Heiden, Aaron N. Hata, Zucai Suo, Lee Zou

The paper shows genomic uracil induces DNA replication stress without BER processing and identifies UNG2 upregulation as a vulnerability in cancer cells.

Molecular Cell · Apr 29, 2024Peer-reviewedMolecular Biology