Cancer BiologybioRxivPreprint
Genetic dissection of DNA damage response pathways reveals divergent modulation of PD-1 blockade response in colorectal cancer
Ferran Fece de la Cruz, Edmond Wong, Haley Barnes…·Ryan Bruce Corcoran
This study identifies DDR gene alterations that modulate PD-1 blockade response in MSS colorectal cancer, showing that some defects enhance immunotherapy while others reduce benefit.
DOI 10.64898/2026.10.03.756428