Ryan Bruce Corcoran

This study identifies DDR gene alterations that modulate PD-1 blockade response in MSS colorectal cancer, showing that some defects enhance immunotherapy while others reduce benefit.

This study uses quantitative imaging to analyze schwannoma heterogeneity and test drugs in a mouse model, revealing distinct therapeutic response signatures.

The paper identifies adaptive plasticity tumor (APT) cells that reduce response to MAPK inhibitors in colorectal cancer by increasing stemness and ASCL2 expression, and shows that targeting APT cells improves therapy efficacy.

This study compares the immunological effects of photon and proton radiation therapy in cancer patients, finding that proton therapy preserves T cell diversity and may improve survival.

This study examines the evolutionary dynamics of peritoneal metastases in colorectal cancer, finding they are more heterogeneous than liver metastases but less diverse than locoregional metastases.