Early demyelination by off-target complement injury in a mouse model of neuromyelitis optica
Selin Kenet, Marina Herwerth, Shahrzad Askari, Katharina Eichenseer, Klaus Dornmair, Xuebin Qin, Christine Stadelmann, Jeffrey L. Bennett, Bernhard Hemmer, Thomas Misgeld
This study shows that in a mouse model of NMOSD, demyelination occurs due to off-target complement injury to oligodendrocytes, not directly from astrocyte loss.
bioRxiv · Mar 17, 2026 · PreprintNeuroscience