Nicolas Snaidero

This study shows that OPCs in aging retain remyelination potential, which can be reactivated by demyelination, improving myelin repair.

The paper investigates the mechanisms of selective cortical myelination, finding that early myelination is axon-driven and influenced by interactions with specific neuronal partners.

The paper shows that single oligodendrocyte loss in mouse cortex triggers precise remyelination and cell replacement, preserving original myelin patterns while creating new internodes on unmyelinated axons.

The paper shows that calcium accumulations in dendritic spines precede their removal by phagocytes in cortical inflammation, and blocking phagocyte activation prevents synapse loss.