Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
Constantine N. Tzouanas, Jessica E.S. Shay, Marc Samuel Sherman, Adam J. Rubin, Benjamin E. Mead, Tyler T. Dao, Junyan Tao, Brandon M. Lehrich, George M. Eng, Jeffrey Patterson-Fortin, Titus Butzlaff, Miyeko Mana, Kellie E. Kolb, Chad Michael Walesky, Brian J. Pepe-Mooney, , Alex K. Shalek
The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.
Cell · Dec 22, 2025Peer-reviewedSystems Biology