Author
Massachusetts General HospitalORCID 0000-0003-0272-9623Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Yetiş Gültekin, Sharanya Sivanand, Kian Moritz Eghbalian…·Matthew G. Vander Heiden
This study shows pancreatic cancer disrupts normal pancreatic function, leading to systemic nutrient depletion and muscle wasting, with autophagy in muscle playing a key role in nutrient redistribution to support tumor growth.
Constantine N. Tzouanas, Jessica E.S. Shay, Marc Samuel Sherman…·Alex K. Shalek
The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.
George M. Eng, Jonathan Braverman, Manish K. Gala, Ömer H. Yilmaz
This paper identifies a therapeutic strategy using WNT hyperactivation to kill colorectal cancer cells while rejuvenating healthy intestinal tissue.
William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo…·Aviv Regev
This study uses single-nucleus and spatial transcriptomics to analyze pancreatic cancer before and after neoadjuvant treatment, revealing changes in cell states and immune infiltration that may inform therapy.
Martin S. Taylor, Ilya A. Altukhov, Kelly R. Molloy…·John LaCava
The paper identifies distinct nuclear and cytoplasmic intermediates of LINE-1 retrotransposition using mass spectrometry and affinity purification.