Author

Brian J. Pepe-Mooney

Brigham and Women's HospitalORCID 0009-0002-7516-423XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Colton J. SmithiD· 2 shared Marc Samuel ShermaniD· 2 shared Wolfram GoesslingiD· 2 shared Adam J. RubiniD· 1 shared Adrian J. McNairniD· 1 shared Alaa R. FarghliiD· 1 shared Alex K. ShalekiD· 1 shared Andreas StephanouiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSystems Biology

Colton J. SmithORCID

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2 papers

Recent·Most cited

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival

Constantine N. Tzouanas, Jessica E.S. Shay, Marc Samuel Sherman, Adam J. Rubin, Benjamin E. Mead, Tyler T. Dao, Junyan Tao, Brandon M. Lehrich, George M. Eng, Jeffrey Patterson-Fortin, Titus Butzlaff, Miyeko Mana, Kellie E. Kolb, Chad Michael Walesky, Brian J. Pepe-Mooney, , Alex K. Shalek

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

Cell · Dec 22, 2025Peer-reviewedSystems Biology

Single-cell multi-omic analysis of fibrolamellar carcinoma reveals rewired cell-to-cell communication patterns and unique vulnerabilities

Alaa R. Farghli, Marina Chan, Marc Samuel Sherman, Lindsay K. Dickerson, Bo Shui, Manabu Nukaya, Andreas Stephanou, Rosanna K. Ma, Brian J. Pepe-Mooney, Colton J. Smith, Donald Long, Paul R. Munn, Adrian J. McNairn, Jennifer K. Grenier, Michael Karski, , Praveen Sethupathy

This study uses single-nucleus multi-omics to analyze fibrolamellar carcinoma, revealing rewired cell communication and potential therapeutic targets.

bioRxiv · Dec 11, 2024 · PreprintCancer Biology