Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia
Michael D. Gallagher, Xochitl Luna, Wenjuan Du, Kathryn E.A. Hazel, Moritz List, Zeynep Aydin, Orian Stapleton, Yiran Cheng, Bingbing Yuan, Keya Viswanathan, Heather R. Keys, George W. Bell, Dheeraj Malhotra, Richard A. Young, Rudolf Jaenisch, Olivia Corradin
The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.
medRxiv · Jun 16, 2025 · PreprintGenetic & Genomic Medicine