Heather R. Keys

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

This study identifies gene targets involved in cell-substrate adhesion through functional genetic analyses in human cells, revealing dynamic requirements and novel regulators.

This study identifies lysosomal RNases and shows specific RNA types are targeted for degradation via autophagy-dependent mechanisms.

The paper identifies KIF18A as a gene whose knockout causes synthetic lethality with a hypomorphic CENP-C mutant, revealing a regulatory system for chromosome congression.

The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.

This paper introduces a genetically encoded fluorescent reporter for real-time measurement of polyamine levels in single cells and identifies a link between mitochondrial respiration and polyamine import in Parkinson's disease.

The paper identifies gene targets that modulate sensitivity to anti-microtubule drugs using CRISPR screens in human cells.

This study identifies GPX4 as a conserved suppressor of cold-induced cell death through multi-species CRISPR screens in hibernators and non-hibernators.

The paper identifies a targeted degradation pathway for nascent proteins from PTC-containing mRNAs, showing CNOT4's role in coupling NMD with protein quality control.

This paper develops a method for genome-scale CRISPR screening in a single mouse liver to study cellular fitness regulation in vivo.

The paper identifies juxtacap nucleotide sequences that modulate eIF4E binding and translation, showing context-dependent effects on ribosome occupancy and translation efficiency.