APOE4-Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation in preclinical Alzheimer's disease
Jia Shin, Erica S Brady, Chun Chen, Kelli Lauderdale, Ayushi Agrawal, Yutong Zhang, Xueqiao Jiang, Pranav Nambiar, Jessica Herbert, Dakota D. Mallen, Katie K. Ly, Patrick S. Honma, Zhongyi Guo, Cathrine Sant, Reuben Thomas, , Jorge J. Palop
This study investigates how APOE4 and Aβ interact in preclinical Alzheimer's disease, finding their synergistic effects on neuronal proteostasis and network dysfunction.
bioRxiv · Nov 11, 2025 · PreprintNeuroscience