Author

Zhongyi Guo

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Cathrine Sant· 2 shared Amalia PernaiD· 1 shared Angie Spence· 1 shared Ayushi AgrawaliD· 1 shared Birgitt SchüleiD· 1 shared Bryan J. CannoniD· 1 shared Chun CheniD· 1 shared Dakota D. Mallen· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Cathrine Sant

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease

Rachel Ee, Meelad Amouzgar, Jumana Afaghani, Kausalia Vijayaragavan, Bryan J. Cannon, Dunja Mrdjen, Dmitry Tebaykin, Angie Spence, Cathrine Sant, David Aley, Zhongyi Guo, Kamilla Sedov, Faria Zafar, Kathleen S. Montine, Amalia Perna, , Sean C. Bendall

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

bioRxiv · Jun 19, 2026 · PreprintImmunology

APOE4-Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation in preclinical Alzheimer's disease

Jia Shin, Erica S Brady, Chun Chen, Kelli Lauderdale, Ayushi Agrawal, Yutong Zhang, Xueqiao Jiang, Pranav Nambiar, Jessica Herbert, Dakota D. Mallen, Katie K. Ly, Patrick S. Honma, Zhongyi Guo, Cathrine Sant, Reuben Thomas, , Jorge J. Palop

This study investigates how APOE4 and Aβ interact in preclinical Alzheimer's disease, finding their synergistic effects on neuronal proteostasis and network dysfunction.

bioRxiv · Nov 11, 2025 · PreprintNeuroscience