Xueqiao Jiang

This study shows that blocking fibrin-microglia interactions reduces AD-related brain network dysfunction and behavioral issues in mice.

This study investigates how APOE4 and Aβ interact in preclinical Alzheimer's disease, finding their synergistic effects on neuronal proteostasis and network dysfunction.

This study shows that multisensory gamma stimulation improves cognitive function and adult neurogenesis in Ts65Dn mice, a model of Down syndrome.

The paper identifies cell-type-specific molecular changes in cerebrovascular cells across brain regions in Alzheimer's Disease, linking them to genetic variants and potential therapeutic targets.

The paper uses single-cell transcriptomics to analyze the hippocampus and entorhinal cortex in Alzheimer's disease, identifying stage-specific molecular changes across cell types.

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.