Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation
Christina N. Vallianatos, Brynne Raines, Robert S. Porter, Katherine M. Bonefas, Michael C. Wu, Patricia Marie Garay, Katie M. Collette, Young Ah Seo, Yali Dou, Catherine E. Keegan, Natalie Celia Tronson, Shigeki Iwase
This study shows that KMT2A and KDM5C, which have opposing enzymatic activities, work together to regulate neuronal structure, behavior, and H3K4 methylation, with their combined loss reversing some phenotypes.
Communications Biology · Jun 1, 2020Peer-reviewedGenetics