Katherine M. Bonefas

POGZ safeguards neuronal gene chromatin architecture and transcription

This paper investigates the role of POGZ in maintaining chromatin architecture and transcription in the developing mouse cortex, finding that its loss disrupts H3K9me3 distribution and impairs neuronal gene expression.

Division of labor among H3K4 Methyltransferases Defines Distinct Facets of Homeostatic Plasticity

This study identifies distinct roles of H3K4 methyltransferases in synaptic scaling, showing that different KMT2 subfamilies are required for upscaling or downscaling.

A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21A

The paper identifies neuron-specific microexon splicing in chromatin regulators, showing that PHF21A loses DNA-binding function in neurons while retaining H3K4me0 recognition, contributing to brain development.

KDM5C is a sex-biased brake against germline gene expression programs in somatic lineages

The paper investigates how KDM5C regulates germline gene repression in somatic cells, revealing sex-biased mechanisms and distinct regulatory classes of germline genes.

Alcohol-specific transcriptional dynamics of memory reconsolidation

The paper identifies alcohol-specific transcriptional changes during memory reconsolidation using mouse models and RNA-sequencing.

LSD1/KDM1A Maintains Genome-wide Homeostasis of Transcriptional Enhancers

This study shows LSD1/KDM1A suppresses primed enhancers in mESC by maintaining H3K4me1 levels and preventing aberrant enhancer activity.

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation

This study shows that KMT2A and KDM5C, which have opposing enzymatic activities, work together to regulate neuronal structure, behavior, and H3K4 methylation, with their combined loss reversing some phenotypes.