Yali Dou

Division of labor among H3K4 Methyltransferases Defines Distinct Facets of Homeostatic Plasticity

This study identifies distinct roles of H3K4 methyltransferases in synaptic scaling, showing that different KMT2 subfamilies are required for upscaling or downscaling.

Revealing long-range heterogeneous organization of nucleoproteins with N6-methyladenine footprinting

The paper develops a novel 6mA-calling pipeline for SMRT sequencing data, improving accuracy and efficiency, and applies it to map nucleosome positioning and transcription factor occupancy at single-molecule resolution.

Semi-conservative transmission of DNA N6-adenine methylation in a unicellular eukaryote

The paper demonstrates that DNA N6-adenine methylation (6mA) is transmitted semi-conservatively in Tetrahymena thermophila, with AMT1-dependent maintenance and AMT1-independent de novo methylation mechanisms.

MOF-mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions by Controlling Gene Promoters

This study shows that MOF-mediated H4K16ac is essential for mitochondrial and ciliary functions in mammalian skin development, with loss of MOF causing severe developmental defects.

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation

This study shows that KMT2A and KDM5C, which have opposing enzymatic activities, work together to regulate neuronal structure, behavior, and H3K4 methylation, with their combined loss reversing some phenotypes.

Developmental Reactive Oxygen Species Target Histone Methylation to Individualize Stress resistance and Lifespan

The paper shows that early developmental ROS increases stress resistance and lifespan by reducing histone H3K4me3 levels in C. elegans and mammalian cells.