Eric L. Lindberg

Spatial proteomics reveals mechanisms of cell-intrinsic tryptophan metabolism controlling ovarian cancer survival

The paper uses spatial proteomics to show IDO1's tumor-suppressive role in ovarian cancer by linking it to tryptophan metabolism and stress response pathways.

Mechanosensitive PIEZO2 channels shape coronary artery development

This study shows PIEZO2 channels are critical for coronary artery development, as their absence causes vessel malformations and cardiac issues in mice.

Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered

This paper identifies direct cardiomyocyte toxicities of IL11 therapy, showing it causes acute heart failure by activating JAK/STAT3, which questions its continued use in patients.

Coronary vessel assembly involves patterned endocardial sprouting and tip-cell-to artery specification

This study identifies endocardial sprouting angiogenesis as a key mechanism in coronary vessel formation, revealing distinct molecular profiles that shape coronary arteries and veins.

Cells and gene expression programs in the adult human heart

The paper characterizes the cellular composition and gene expression of the adult human heart using single-cell transcriptomics, identifying distinct cell types and their functional roles.