Author

Thierry Gostan

Centre National de la Recherche ScientifiqueORCID 0000-0002-1087-8015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Adèle L’Hostis· 1 shared Alja Kozulic-Pirher· 1 shared Amal Zine El AabidineiD· 1 shared Camille BellièresiD· 1 shared Édouard BertrandiD· 1 shared Encar García-OliveriD· 1 shared Eugenia I. BasyukiD· 1 shared Florian MuelleriD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperSystems Biology

Adèle L’Hostis

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

RNA dysregulation and compromised neuronal identity drive pathogenesis in Senataxin-associated ALS

Marta Giannini, Thierry Gostan, Amal Zine El Aabidine, Camille Bellières, Stéphane Nedelec, Odil Porrúa

This study investigates how SETX mutations in ALS4 lead to RNA dysregulation and neuronal dysfunction through TGF-β signaling activation and R-loop metabolism disruption.

bioRxiv · Jul 1, 2026 · PreprintMolecular Biology

Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

Katjana Tantale, Encar García-Oliver, Marie-Cécile Robert, Adèle L’Hostis, Yueyuxiao Yang, Nikolay Tsanov, Rachel Topno, Thierry Gostan, Alja Kozulic-Pirher, Meenakshi Basu Shrivastava, Kamalika Mukherjee, Věra Slaninová, Jean‐Christophe Andrau, Florian Mueller, Eugenia I. Basyuk, , Édouard Bertrand

The paper uses single molecule imaging to study HIV-1 promoter pausing and finds that stochastic pausing leads to transcriptional bursting in latent cells.

Nature Communications · Jul 23, 2021Peer-reviewedSystems Biology