Jean‐Christophe Andrau

The paper shows ECM stiffness alters nuclear lamina composition and PRC2-mediated gene repression through changes in chromatin structure and motion.

This study identifies G-quadruplexes as promoter elements that exclude nucleosomes and facilitate RNA polymerase II pausing.

This study shows that the transcription factor GAF acts as a stable mitotic bookmark during zygotic genome activation in Drosophila embryos, enabling rapid transcriptional activation after mitosis.

The paper uses single molecule imaging to study HIV-1 promoter pausing and finds that stochastic pausing leads to transcriptional bursting in latent cells.