Targeted disruption of linkage-specific ubiquitylation reveals a key role of K29-linked ubiquitylation in epigenome integrity
Javier Arroyo-Gomez, Matthew J Murray, Claire Guérillon, Juanjuan Wang, Ekaterina A. Isaakova, Nazaret Reverón-Gómez, Mikaela Koutrouli, Aldwin Suryo Rahmanto, Katrine Mitrofanov, Andreas Ingham, Sofie Ulfbeck Schovsbo, Katrine Weischenfeldt, Fabian Coscia, Dimitris Typas, Moritz Carl Völker-Albert, , Niels Mailand
This study uses a ubiquitin replacement strategy to show K29-linked ubiquitylation regulates SUV39H1 stability and H3K9me3 levels in human cells.
The EMBO Journal · Oct 22, 2025Peer-reviewedCell Biology