Ribonuclease L Regulates Antiviral Responsiveness through Cleavage of XBP1 mRNA
Yoshika Takenaka, Yasutoshi Akiyama, 稲葉翼, Daiki Shinozuka, Katsuki Aoyama, Ransu Ogasawara, Nana Kunii, Takaaki Abe, Eiji Morita, Yoshihisa Tomioka, Pavel V. Ivanov
The paper shows RNase L suppresses XBP1s, which fine-tunes antiviral responses by negatively regulating RIG-I-like receptors, RNase L, and PKR pathways.
bioRxiv · Mar 23, 2026 · PreprintMolecular Biology