Takaaki Abe

The paper shows RNase L suppresses XBP1s, which fine-tunes antiviral responses by negatively regulating RIG-I-like receptors, RNase L, and PKR pathways.

This study shows microgravity reduces mechanoreceptor gene expression in C. elegans, causing neuromuscular defects and accelerated aging, but physical stimulation in space can reverse these effects.

This paper develops a human vascular model using iPSC-derived cells that mimics vascular aging phenotypes and responds to vasoactive stimuli, showing potential for aging research and drug discovery.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

This study shows that BACH1 maintains labile iron levels in HNSCC cells, preventing metabolic cell death and enabling proliferation, and that BACH1 inhibition enhances the effect of tipifarnib.

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

The paper establishes a novel ATP imaging system using kidney slice cultures to study intracellular ATP dynamics under pathophysiological conditions and evaluates ATP synthesis pathways in different kidney cell types.

The paper shows that tRNA processing in human cells occurs primarily in the cytoplasm, challenging the notion that it is entirely nuclear.

This study identifies mitochondrial dysfunction in sporadic inclusion body myositis and shows that MA-5 improves mitochondrial function and protects myoblasts.

This study investigates how Alkbh1 affects tRNA cleavage and tiRNA generation under stress in rat cells, showing stress-specific impacts and differential tRNA cleavage.

The paper shows that multiple RNase A family members cleave tRNAs under stress, producing tiRNAs that aid in translational reprogramming.