tRNA-derived fragments elevated in Alzheimer's disease facilitate Tau aggregation
Ami Kobayashi, Chung-Ta Han, Lien Nguyen, Karen Tsay, M Martins, Prakash Kharel, Yanhong Zhang, M. Inmaculada Barrasa, Allison M. Williams, Nana Kunii, Yasutoshi Akiyama, Vikram Khurana, Bradley T. Hyman, Pavel Ivanov, Songi Han, Anna M. Krichevsky
This study identifies tRNA-derived fragments (tRFs) as key regulators of Tau aggregation in Alzheimer's disease and shows their potential as therapeutic targets.
bioRxiv · Jul 10, 2026 · PreprintNeuroscience