Yasutoshi Akiyama

This study identifies tRNA-derived fragments (tRFs) as key regulators of Tau aggregation in Alzheimer's disease and shows their potential as therapeutic targets.

The paper shows RNase L suppresses XBP1s, which fine-tunes antiviral responses by negatively regulating RIG-I-like receptors, RNase L, and PKR pathways.

The paper shows that cleavage of tRNA isodecoders generates tRNA-derived RNAs (tDRs) with differential activities in mRNA reporter translation, suggesting a mechanism for repurposing tRNAs for non-canonical functions.

The paper shows that tRNA processing in human cells occurs primarily in the cytoplasm, challenging the notion that it is entirely nuclear.

This study identifies mitochondrial dysfunction in sporadic inclusion body myositis and shows that MA-5 improves mitochondrial function and protects myoblasts.

The paper shows that multiple RNase A family members cleave tRNAs under stress, producing tiRNAs that aid in translational reprogramming.