Yoshihisa Tomioka

The paper shows RNase L suppresses XBP1s, which fine-tunes antiviral responses by negatively regulating RIG-I-like receptors, RNase L, and PKR pathways.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.