Renal proximal tubules are sensitive to metabolic acidosis
J. Christopher Hennings, Keerthana S. Murthy, Nicolas Picard, Inês Cabrita, David Böhm, Maria E. Krause, Vandit Shah, Jennifer Baraka-Vidot, Mukhran Khundadze, Tobias Stauber, Detlef Böckenhauer, Thomas J. Jentsch, Sebastian Bachmann, Bernhard Schermer, Dominique Eladari, , Christian Andreas Hübner
This paper shows that proximal tubules are sensitive to metabolic acidosis, leading to trafficking defects and lysosomal damage, and that bicarbonate therapy can prevent these issues.
bioRxiv · Aug 19, 2024 · PreprintMolecular Biology