Christian Andreas Hübner

This study shows that bacterial LPS binds RETREG1 to induce ER remodeling and enhance antibacterial defense through ERphagy.

This study shows that chronic stress accelerates brain aging in young mice but activates age-specific anti-aging programs in old mice.

This study uses blood vessel organoids to compare gene expression and cellular behavior in CCM1, CCM2, and CCM3 knockout models, revealing distinct functional roles that may explain differing disease severity.

This study shows that mice with SLC4A1 mutations exhibit urinary sodium wasting and disrupted collecting duct function, similar to human dRTA patients.

This paper shows that proximal tubules are sensitive to metabolic acidosis, leading to trafficking defects and lysosomal damage, and that bicarbonate therapy can prevent these issues.

This study identifies Transthyretin as a sex-specific target of vitamin B12 that influences stress resilience through DNA methylation changes in the prefrontal cortex.

This study identifies Npbwr1 as a key regulator of depressive-like symptoms and shows that its antagonist CYM50769 rapidly alleviates these symptoms in mice.

This study compares Triac and Ditpa in Mct8/Oatp1c1 deficient mice, finding Triac more effective in improving CNS development and locomotor function when administered early postnatally.

This study shows that bumetanide treatment after traumatic brain injury increases microglia-interneuron contact and improves cognitive function by altering microglial activation and BDNF expression.

This study shows that NKCC1 deletion in developing mice has minimal impact on hippocampal network development and behavior, challenging its essential role in these processes.

The paper identifies CAP1 as a novel actin regulator in growth cones that is critical for neuron connectivity and function.

This study shows that sensory deprivation of non-visual modalities induces visual cortex plasticity and improves visual performance in adult mice.