Nicolas Picard

Renal adaptation to high salt diet requires tubular Na+ secretion through type A intercalated cells

The paper identifies type A intercalated cells as critical for Na+ secretion in response to high salt diets and shows their absence leads to a Bartter-like phenotype.

Renal proximal tubules are sensitive to metabolic acidosis

This paper shows that proximal tubules are sensitive to metabolic acidosis, leading to trafficking defects and lysosomal damage, and that bicarbonate therapy can prevent these issues.