Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila
Shweta Yadav, Xingxiu Pan, Shengxi Li, Paige LaRae Martin, Ngoc Hoang, Kejin Chen, Aditi Karhadkar, Jatin Malhotra, Austin L. Zuckerman, Subrata Munan, Markus K. Klose, Lin Wang, Valentin Cracan, Andrey A. Parkhitko
This study uses LbNOX in Drosophila to show tissue-specific effects of NADH/NAD+ modulation on aging, revealing that targeting non-neuronal tissues can rejuvenate sleep in aged flies.
bioRxiv · Jan 6, 2025 · PreprintSynthetic Biology