Markus K. Klose

The paper investigates how s-LNv clock neurons regulate sleep through neuropeptide release and cytoneme-mediated communication with l-LNv neurons.

The paper shows that Drosophila clock neurons capture circulating neuropeptide vesicles in anticipation of release, independent of axonal expansion or calcium signaling.

This study uses LbNOX in Drosophila to show tissue-specific effects of NADH/NAD+ modulation on aging, revealing that targeting non-neuronal tissues can rejuvenate sleep in aged flies.

The paper investigates the timing mismatch between somatic Ca2+ activity and neuropeptide release in Drosophila sLNv neurons, finding that terminal Ca2+ spiking and neuropeptide release peak midmorning, hours before their behavioral effects.

The paper shows that dFB neurons in Drosophila adjust their response properties based on environmental demands and prior metabolic challenges to regulate sleep drive.

The paper shows that Drosophila clock neurons release neuropeptides from different compartments at different times, with somatic release controlled by IP3 and terminal release by Ca2+.

This study shows that high sleep-pressure in Drosophila reprograms clock neurons to express the Pigment Dispersing Factor receptor, enhancing waking and mating success.