Valentin Cracan

This paper identifies a strategy combining NAMPT activation and NAM supplementation to target NAD+ dysregulation and senescent cells, promoting healthy aging in mice.

This study identifies CtBP as a redox state sensor that controls enteroendocrine cell fate in Drosophila by integrating metabolic signals with transcriptional regulation.

This paper develops a genetically encoded bifunctional enzyme that reduces redox imbalance and lipotoxicity by enhancing Gro3P biosynthesis and glycerol shunt in mammalian cells.

This study uses LbNOX in Drosophila to show tissue-specific effects of NADH/NAD+ modulation on aging, revealing that targeting non-neuronal tissues can rejuvenate sleep in aged flies.