Author

Shengxi Li

Chinese Academy of Medical Sciences & Peking Union Medical College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Physiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:metabolomics· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Lin Wang· 3 shared Andrey A. ParkhitkoiD· 2 shared Shweta YadaviD· 2 shared Aditi Karhadkar· 1 shared Austin L. ZuckermaniD· 1 shared Binzhi Qian· 1 shared Chuangyi HaniD· 1 shared Daoliang ZhangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioinformatics

Lin Wang

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Author profile →

4 papers

Recent·Most cited

Deciphering the gene-centric spatial dynamics across tissue and time with GeneSPOT

Qi Zou, Zhikang Wang, Sijie Li, Senlin Lin, Chuangyi Han, Yan Cui, Shengxi Li, Lin Wang, Daoliang Zhang, Wei Zhang, Binzhi Qian, Rui Gao, Zhiyuan Yuan

GeneSPOT is a gene-centric framework that characterizes spatial gene relationships and their reorganization across biological conditions and time.

bioRxiv · Sep 29, 2026 · PreprintBioinformatics

Stromal asparagine supports tumor adaptation to oxidative phosphorylation inhibition through SLC38A4-mediated metabolic coupling

Ziyi Qin, Shengxi Li, Yeting Xu, Jiaming Zou, Jinyang Ma, Yingying Wang, Yucheng Wang, Rui Jü, Lin Wang, Lei Guo

This study identifies asparagine (ASN) as a critical metabolite supplied by cancer-associated fibroblasts (CAFs) to pancreatic ductal adenocarcinoma (PDAC) cells under oxidative phosphorylation (OXPHOS) inhibition, revealing SLC38A4 as a mediator of metabolic coupling that supports tumor adaptation.

bioRxiv · Mar 18, 2026 · PreprintCancer Biology

Mutation of an insulin-sensitive Drosophila insulin-like receptor mutant requires methionine metabolism reprogramming to extend lifespan

Marc Tatar, Wenjing Zheng, Shweta Yadav, Rochele Yamamoto, Noelle Curtis-Joseph, Shengxi Li, Lin Wang, Andrey A. Parkhitko

This paper shows a Drosophila insulin-like receptor mutation extends lifespan by reprogramming methionine metabolism, avoiding insulin resistance and maintaining growth and reproduction.

bioRxiv · Feb 28, 2025 · PreprintPhysiology

Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila

Shweta Yadav, Xingxiu Pan, Shengxi Li, Paige LaRae Martin, Ngoc Hoang, Kejin Chen, Aditi Karhadkar, Jatin Malhotra, Austin L. Zuckerman, Subrata Munan, Markus K. Klose, Lin Wang, Valentin Cracan, Andrey A. Parkhitko

This study uses LbNOX in Drosophila to show tissue-specific effects of NADH/NAD+ modulation on aging, revealing that targeting non-neuronal tissues can rejuvenate sleep in aged flies.

bioRxiv · Jan 6, 2025 · PreprintSynthetic Biology