Familial Danish dementia young Knock-in rats expressing humanized APP and human Aβ show impaired pre and postsynaptic glutamatergic transmission
Tao Yin, Wen Yao, Kelly A. Norris, Luciano D'adamio
The paper investigates early pathogenic changes in young rats with the Danish mutation in Itm2b, showing altered glutamatergic synaptic function and human Aβ levels.
bioRxiv · Jun 24, 2021 · PreprintNeuroscience