NeurosciencebioRxivPreprint
TNFα reduces inhibitory transmission in young Trem2R47H Sporadic Alzheimer rats before observable Aβ and brain pathology
Siqiang Ren, Lionel Breuillaud, Wen Yao…·Luciano D'adamio
The paper shows that the p.R47H TREM2 variant reduces GABAergic transmission in young Alzheimer rats, mediated by TNF-α, before Aβ accumulation and brain pathology.
DOI 10.1101/2020.08.20.256099