A photoswitchable GPCR-based opsin for presynaptic silencing
Bryan A. Copits, Raaj Gowrishankar, Patrick O’Neill, Jun-Nan Li, Kasey S. Girven, Judy J. Yoo, Xenia Meshik, Kyle E. Parker, Skylar M. Spangler, Abigail J. Elerding, Bobbie J. Brown, Sofia E. Shirley, Kelly K.L., Alexis M. Vasquez, M. Christine Stander, , Michael R. Bruchas
This paper introduces parapinopsin (PPO), a photoswitchable GPCR-based opsin that enables rapid and reversible presynaptic inhibition, and demonstrates its utility in vivo.
Neuron · May 11, 2021Peer-reviewedNeuroscience