Jessica R. Tooley

Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systems

The paper develops a CRISPR/Cas9 gene editing strategy using a single AAV vector and Cre-dependent Cas9 in mice to enable cell-type specific editing and tool delivery in the nervous system.

A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits

This paper identifies PdCO as a bistable GPCR with high temporal precision for optogenetic control of neural circuits in vivo.

Oral oxycodone self-administration leads to features of opioid addiction in male and female mice

This study shows that oral oxycodone self-administration in mice leads to features of opioid addiction, including escalation, dependence, and relapse behavior.

A photoswitchable GPCR-based opsin for presynaptic silencing

This paper introduces parapinopsin (PPO), a photoswitchable GPCR-based opsin that enables rapid and reversible presynaptic inhibition, and demonstrates its utility in vivo.

Modeling features of addiction with an oral oxycodone self-administration paradigm

This paper introduces an oral oxycodone self-administration paradigm in mice to model prescription opioid use and its transition to abuse.

Ventral arkypallidal neurons modulate accumbal firing to promote reward consumption.

This study identifies a specific subpopulation of ventral pallidal neurons that modulate nucleus accumbens firing to enhance reward consumption.