Author

Sofia E. Shirley

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Abigail J. Elerding· 2 shared Lin TianiD· 2 shared Michael R. BruchasiD· 2 shared Adam Gordon-FennelliD· 1 shared Alexis M. Vasquez· 1 shared Bobbie J. BrowniD· 1 shared Bryan A. CopitsiD· 1 shared Chunyang DongiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Abigail J. Elerding

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2 papers

Recent·Most cited

Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to control goal-directed action

Raajaram Gowrishankar, Madelyn M. Hjort, Abigail J. Elerding, Sofia E. Shirley, Josie Van Tilburg, David J. Marcus, Pranav Senthilkumar, Khalid Abrera, Dustin Sumarli, Katherine Motovilov, Valerie Lau, Adam Gordon-Fennell, Zhe Charles Zhou, Chunyang Dong, Lin Tian, , Michael R. Bruchas

This study identifies the role of endogenous dynorphin release in the dorsal striatum in regulating goal-directed behavior through retrograde GPCR inhibition.

bioRxiv · May 20, 2024 · PreprintNeuroscience

A photoswitchable GPCR-based opsin for presynaptic silencing

Bryan A. Copits, Raaj Gowrishankar, Patrick O’Neill, Jun-Nan Li, Kasey S. Girven, Judy J. Yoo, Xenia Meshik, Kyle E. Parker, Skylar M. Spangler, Abigail J. Elerding, Bobbie J. Brown, Sofia E. Shirley, Kelly K.L., Alexis M. Vasquez, M. Christine Stander, , Michael R. Bruchas

This paper introduces parapinopsin (PPO), a photoswitchable GPCR-based opsin that enables rapid and reversible presynaptic inhibition, and demonstrates its utility in vivo.

Neuron · May 11, 2021Peer-reviewedNeuroscience