Evasion of neutrophil-mediated bacterial clearance in Pseudomonas aeruginosa isolates from new-onset infections in cystic fibrosis children
Kelly Kwong, Sophia Goldman, Annie Beauchamp, Julien Karim Malet, Inès Levade, Lucia Grana, David S. Guttman, Valerie J. Waters, Dao M. Nguyen
This study shows that Pseudomonas aeruginosa isolates from CF patients who failed eradication therapy resist neutrophil-mediated clearance due to loss of Type IV pilus-mediated twitching motility, contributing to infection persistence.
bioRxiv · Sep 29, 2024 · PreprintMicrobiology