Author

Valerie J. Waters

Hospital for Sick ChildrenORCID 0000-0003-1566-6510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

David S. GuttmaniD· 2 shared Annie Beauchamp· 1 shared Dao M. NguyeniD· 1 shared David M. HwangiD· 1 shared Inès LevadeiD· 1 shared Julien Karim MaletiD· 1 shared Kelly Kwong· 1 shared Lucia Grana· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

David S. GuttmanORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 29, 2024

Evasion of neutrophil-mediated bacterial clearance in Pseudomonas aeruginosa isolates from new-onset infections in cystic fibrosis children

Kelly Kwong, Sophia Goldman, Annie Beauchamp…·Dao M. Nguyen

This study shows that Pseudomonas aeruginosa isolates from CF patients who failed eradication therapy resist neutrophil-mediated clearance due to loss of Type IV pilus-mediated twitching motility, contributing to infection persistence.

DOI 10.1101/2024.09.29.615549

mouseexperimental assay

𝕏 PostBluesky

GenomicsbioRxivPreprintOct 25, 2022

Predictive modeling of antibiotic eradication therapy success for new-onset Pseudomonas aeruginosa pulmonary infections in children with cystic fibrosis

Lucía Graña-Miraglia, Nadia P. Morales-Lizcano, Pauline W. Wang…·David S. Guttman

The paper uses machine learning to predict antibiotic eradication therapy success for Pseudomonas aeruginosa infections in cystic fibrosis patients based on genomic data, achieving an AUC of 0.87.

DOI 10.1101/2022.10.25.513740

humanDNA methylation

𝕏 PostBluesky