David S. Guttman

This study shows that CAR1-mediated recognition of the effector AvrE1 enhances stomatal immunity in Arabidopsis, preventing P. syringae leaf invasion.

The paper identifies QSK1 as a novel negative regulator of PRR-RBOHD complex and shows it is targeted by the bacterial effector HopF2Pto to suppress plant immunity.

This study shows that Pseudomonas aeruginosa isolates from CF patients who failed eradication therapy resist neutrophil-mediated clearance due to loss of Type IV pilus-mediated twitching motility, contributing to infection persistence.

This study examines the impact of gestational diabetes on infant gut microbiome function and composition, finding modest and transient effects.

The paper uses machine learning to predict antibiotic eradication therapy success for Pseudomonas aeruginosa infections in cystic fibrosis patients based on genomic data, achieving an AUC of 0.87.

This paper uses gradient boosted decision trees to predict virulence of Pseudomonas syringae isolates on bean using genomic data, finding that PG3 strains are more host-specific than PG2 strains.

The paper introduces RecPD, a recombination-aware phylogenetic diversity metric, and demonstrates its utility in analyzing feature evolution under recombination and horizontal transfer.

The paper analyzes the global spread and structural impact of the D614G mutation in the SARS-CoV-2 spike protein, finding it predominant in Europe and neutral in function regarding ACE2 receptor binding.

The paper identifies genetic variants associated with enhanced growth and reduced immune function in modern broilers through comparative genomic analysis of historical and commercial chicken lines.

This study shows that perturbations of the ZED1 pseudokinase activate plant immunity by forming a ternary complex with PBL kinases and ZAR1, independent of the effector HopZ1a.

The paper analyzes the evolutionary relationships of Pseudomonas syringae strains using whole-genome sequencing and finds that recombination maintains genetic cohesion, particularly among primary phylogroups.

The paper identifies HopZ1a, a T3SE from Pseudomonas syringae, as an acetyltransferase that targets plant kinesins to disrupt microtubule networks through yeast genetic and interaction screens.