Disease related changes in ATAC-Seq of more than 450 iPSC-derived motor neuron lines from ALS patients and controls
Stanislav Tsitkov, Kelsey Valentine, Velina Kozareva, Aneesh Donde, Aaron P. Frank, Susan Lei, Jennifer E. Van Eyk, Steven M. Finkbeiner, Jeffrey D. Rothstein, Leslie Michels Thompson, Dhruv Sareen, Clive Niels Svendsen, Ernest Fraenkel
The paper analyzes ATAC-seq data from iPSC-derived motor neurons of ALS patients and controls to identify disease-specific chromatin accessibility changes and their predictive power for disease progression.
bioRxiv · Sep 11, 2023 · PreprintNeuroscience