Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging
Sen Zhang, Charles E. Ayemoba, Anna M. Di Staulo, Kenneth Joves, Chandani M. Patel, Eva Hin Wa Leung, Maura Lima Pereira Bueno, Xiaoping Du, Mortimer Poncz, Sang‐Ging Ong, Claus Nerlov, Maria Maryanovich, Constantinos Chronis, Sandra Pinho
This study identifies PF4 as a key regulator of HSC aging, showing that PF4 deficiency accelerates aging and that PF4 supplementation can rejuvenate aged HSCs.
Blood · Sep 8, 2025Peer-reviewedCell Biology