Author

Claus Nerlov

University of OxfordORCID 0000-0002-0544-735XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Alexis Georgiades· 1 shared Ali Toghani· 1 shared Amogh Pradeep· 1 shared Anna M. Di StauloiD· 1 shared Antonio ScialdoneiD· 1 shared Atsushi KumanogohiD· 1 shared Berthold GöttgensiD· 1 shared Bongsoo ParkiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCell Biology

Alexis Georgiades

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Deep learning enables cross-species annotation and attribution of ageing states in haematopoietic stem and immune cells

Simiao Zhao, Bowen Zhang, Melinda Czéh-Bhardwaj, Xuehao Zhai, Niels Asger Jakobsen, Christopher Yau, Píetro Lió, Claus Nerlov

The paper develops a cross-species deep learning framework to annotate and attribute ageing states in haematopoietic stem and immune cells, achieving high AUROC scores in human data.

bioRxiv · Jul 26, 2026 · PreprintBioinformatics

Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging

Sen Zhang, Charles E. Ayemoba, Anna M. Di Staulo, Kenneth Joves, Chandani M. Patel, Eva Hin Wa Leung, Maura Lima Pereira Bueno, Xiaoping Du, Mortimer Poncz, Sang‐Ging Ong, Claus Nerlov, Maria Maryanovich, Constantinos Chronis, Sandra Pinho

This study identifies PF4 as a key regulator of HSC aging, showing that PF4 deficiency accelerates aging and that PF4 supplementation can rejuvenate aged HSCs.

Blood · Sep 8, 2025Peer-reviewedCell Biology

Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool

Dorsa Toghani, Sanika Gupte, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani, Christian S. Burns, David M. Gravano, Stefan Radtke, Hans‐Peter Kiem, Sonia Rodrı́guez, Nadia Carlesso, Amogh Pradeep, Alexis Georgiades, Fabienne McClanahan Lucas, , Lev Silberstein

This study identifies Sema4A as an extrinsic factor that protects myeloid-biased HSCs from inflammatory stress, preserving functional diversity in the hematopoietic stem cell pool.

Nature Aging · Jan 29, 2025Peer-reviewedCell Biology