The nucleolus is a mechanosensitive condensate that adapts ribosome biogenesis to mechanical forces
Yuthika Shetty, Kenny Elias, Sara Badawi, Lydia Pernet, Anne‐Sophie Ribba, Christiane I. Oddou, Ludivine Wacheul, Lucid Belmudes, Eve Moutaux, Christiane Zorbas, Sandrine Fraboulet, Yohann Couté, Fabian Erdel, Denis L. J. Lafontaine, Monika E. Dolega
This study shows mechanical compression remodels the nucleolus, reduces rDNA transcription, and identifies nucleolin as a mediator of this response through biophysical and epigenetic mechanisms.
bioRxiv · Jul 3, 2026 · PreprintCell Biology