Christiane I. Oddou

This study identifies PIEZO1, TRPV2, and TRPV4 as mechanosensors overexpressed in CCM lesions, showing their role in driving disease through altered adhesion and matrix degradation.

This study identifies HCK signaling as a driver of long-distance ECM degradation in macrophages through endo-exocytosis coupling involving MMPs and cathepsins.

This study shows mechanical compression remodels the nucleolus, reduces rDNA transcription, and identifies nucleolin as a mediator of this response through biophysical and epigenetic mechanisms.

This study uses optogenetic tools to reveal distinct functional roles of SRC and HCK kinases in macrophages, despite their redundancy.

The paper investigates how mechanical stress is dissipated in folded epithelia, revealing that calcium waves and nuclear tension changes coordinate this process.