Ropinirole hydrochloride mitigates oxidative stress and neuroinflammation via the PI3K-mTOR pathway in TDP-43 hiPSC-derived microglial-like cells
Kagistia Hana Utami, Tatsuya Kozaki, Satoru Morimoto, Hirotaka Watanabe, Kensuke Okada, Nevin Tham, Shinichi Takahashi, Yasue Mitsukura, Hideyuki Okano
This study shows ropinirole hydrochloride reduces oxidative stress and neuroinflammation in TDP-43 mutant microglial-like cells by modulating the PI3K-mTOR pathway.
bioRxiv · Mar 10, 2026 · PreprintNeuroscience