Satoru Morimoto

The paper profiles NHD microglia and shows they adopt an antigen-presenting state without TREM2 dependence, triggering glial-to-neuronal changes.

This study shows ropinirole hydrochloride reduces oxidative stress and neuroinflammation in TDP-43 mutant microglial-like cells by modulating the PI3K-mTOR pathway.

The paper constructs a single-cell atlas of transcribed cis-regulatory elements in the human genome, revealing gene regulation patterns and trait-gene relationships across cell populations.

This study uses cryo-EM to show that tau filaments in ALS/PDC share the CTE fold, suggesting environmental causes for the disease.

This paper introduces a new method to efficiently induce human spinal lower motor neurons from iPSCs and presents a single-cell evaluation system using time-lapse microscopy and machine learning.