Author

Nevin Tham

Nanyang Technological UniversityORCID 0009-0009-1955-2714Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Sarah R. LangleyiD· 2 shared Anna M. BarroniD· 1 shared Hideyuki OkanoiD· 1 shared Hirotaka WatanabeiD· 1 shared Kagistia Hana UtamiiD· 1 shared Kei Onn LaiiD· 1 shared Kensuke Okada· 1 shared Lauren Hermes FairleyiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Sarah R. LangleyORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 10, 2026

Ropinirole hydrochloride mitigates oxidative stress and neuroinflammation via the PI3K-mTOR pathway in TDP-43 hiPSC-derived microglial-like cells

Kagistia Hana Utami, Tatsuya Kozaki, Satoru Morimoto…·Hideyuki Okano

This study shows ropinirole hydrochloride reduces oxidative stress and neuroinflammation in TDP-43 mutant microglial-like cells by modulating the PI3K-mTOR pathway.

DOI 10.64898/2026.03.07.710283

humanstatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 19, 2024

Interaction between mitochondrial translocator protein and aging in inflammatory responses in mouse hippocampus

Kei Onn Lai, Nevin Tham, Lauren Hermes Fairley…·Anna M. Barron

This study examines how aging interacts with TSPO's immunomodulatory role in mouse hippocampus, showing aging reverses TSPO knockout effects and exacerbates inflammation.

DOI 10.1101/2024.06.19.598824

mousebulk RNA-seq

𝕏 PostBluesky

Systems BiologyFrontiers in Systems BiologyPeer-reviewedDec 20, 2022

Evaluating the Robustness of Connectivity Methods to Noise for In Silico Drug Repurposing Studies

Nevin Tham, Sarah R. Langley

This study evaluates connectivity methods for drug repurposing by testing their robustness to noise using gene expression data from the LINCS database.

4 citations

bulk RNA-seqstatistical model

𝕏 PostBluesky